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Dr Charles Knowles

Professor of Surgery & Consultant Colorectal Surgeon

Digestive Disease and Surgery Institute

Sees patients at Cleveland Clinic London Hospital , Portland Place Outpatient Centre

Speaks English

Clinical Interests

  • Anal Fissures
  • Anal Fistula
  • Anal Pain
  • Anorectal Disease
  • Chronic Constipation
  • Crohn's Disease
  • Diverticular Disease
  • Diverticulitis
  • Faecal Incontinence
  • Functional Bowel Disorders
  • Gastrointestinal Neuromuscular Disorders
  • Haemorrhoids
  • Inflammatory Bowel Disease (IBD)
  • Intestinal Pseudo-Obstruction
  • Irritable Bowel Syndrome (IBS)
  • Pelvic Floor Disorders
  • Pelvic Radiation Disease
  • Pilonidal Cyst
  • Rectal Prolapse
  • Ulcerative Colitis


  • Anus and Rectum Surgery
  • Cell and Regenerative Therapies
  • Colorectal Surgery
  • Complex Disease Management
  • Incontinence Surgery
  • Nerve Regeneration
  • Neuromodulation
  • Non-Surgical Treatment of Incontinence
  • Open Hernia Surgery
  • Rectal Prolapse Surgery
  • Re-operative Colorectal Surgery
  • Surgery for Inflammatory Bowel Disease

Biography & Education

About Dr Charles Knowles

Dr Charles Knowles is Lead for Colorectal Surgery at Cleveland Clinic London and Professor of Surgery at Queen Mary University of London. Dr Knowles has been a Consultant Colorectal surgeon at Barts Health NHS Trust since 2006 having qualified from Cambridge University in 1992. He is regarded as a key international opinion leader on pelvic floor disorders and GI neuromuscular diseases including common functional colorectal conditions such as chronic constipation and faecal incontinence. His track record of delivering high-quality research and of shaping clinical practice is evidenced by multiple national and international leadership roles including becoming the inaugural Clinical Director of Research for Cleveland Clinic London. Dr Knowles has published extensively in scientific journals (> 270 peer-reviewed papers) and major textbooks. Professor Knowles lives in Whitechapel, London with his wife, two children, two dogs, cat and collection of guitars. He is also a music artist, songwriter and author.

Research & Publications

See publications for Dr Charles Knowles.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Professional Memberships

Royal College of Surgeons of England, American Society of Colon & Rectal Surgeons, European Society of Coloproctology, Association of Coloproctology of Great Britain & Northern Ireland, Society of Academic and Research Surgery, British Society of Gastroenterology, International Neuromodulation Society, St Marks Association

GMC Number


NHS Base

Barts Health NHS Trust

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